Anton C. de Groot

Anton C. de Groot (1951) has followed his dermatology training in Groningen, The Netherlands, from 1976-1980. After obtaining his license, he has practiced dermatology in the Willem-Alexander Hospital and Carolus-Liduina Hospital in ‘s-Hertogenbosch, The Netherlands. For 5 years he has served as the Chairman of the Board of the Medical Staff.

Adverse reactions to drugs

De Groot became interested in the subject of adverse reactions to drugs after having followed an internschip with prof. Andrew Herxheimer, a dermatologist and pharmacologist in London, from september to december 1975. This lead to his first (co-authored) publication: Herxheimer A, de Groot AC. Some effects of injected hyoscine butylbromide: a versatile class experiment in human pharmacology. Brit J Clin Pharmacol 1977;4:337-342

Bookcover Meylers Side Effects Of Drugs

Chapters in the Meyler’s Side Effects of Drugs series

From 1980 to 2000, he contributed, in the beginning with prof. Johan Nater from Groningen, to the well-known Elsevier series “Meyler’s Side Effects of Drugs” (Meyler was a pharmacology professor in Groningen). His first Chapter was in the 1980 9th Edition of ‘Meyler’ and the coverage was limited to ‘Drugs used on the skin’. In the 14th Edition, twenty years later, the chapter had been expanded to ‘Dermatological drugs, topical agents and Cosmetics’. In this period, 19 yearly ‘Side effects of Drugs Annuals’ were published each containing his chapter with updates of the relevant literature from the previous year.

First book: ‘Unwanted Effects of Cosmetics and Drugs used in Dermatology’

Meanwhile, his interest in adverse reactions to drugs and cosmetics had resulted in the publication of a book on this subject (separate from the Meyler series) titled Unwanted Effects of Cosmetics and Drugs used in Dermatology. The first Edition, which was written in cooperation with Johan Nater, appeared in 1983, already two years later followed by a vastly expanded second edition.

Bookcover Unwanted Effects Edition 1
Bookcover Unwanted Effects Edition 2
Bookcover Unwanted Effects Edition 3
Cover Adverse Reactions To Cosmetics

Thesis: Adverse Reactions to Cosmetics

In the same period, in 1988, De Groot wrote his PhD Thesis on – not quite unexpectedly – the subject Adverse Reactions to Cosmetics. He was one of the first to see the dangers of the cosmetic preservative methylisothiazolinone + methylchloroisothiazolinone (at that time invariably indicated with its trade name Kathon CG) and invited his friend and former teacher Andrew Herxheimer to co-author an article on the ‘epidemic’ of contact allergy to this biocide in The Lancet: De Groot AC, Herxheimer A. Isothiazolinone preservative: cause of a continuing epidemic of cosmetic dermatitis. The Lancet 1989;i:314-316. Previously, their cooperation already had resulted in another publication in The Lancet, about the very limited efficacy of minoxidil in the treatment of male pattern alopecia: De Groot AC, Nater JP, Herxheimer A. Minoxidil: hope for the bald? The Lancet 1987; i: 1019-1022

Editorial activities

Anton de Groot has served on several Editorial boards of scientific journals including “Dermatosen in Beruf und Umwelt”, the “Bulletin Contactdermatoses” and the “Dutch Drugs Bulletin”. He was one of the founders of the “Dutch Journal of Dermatology and Venereology” in 1990. From 1990 until 2010 he served on the Editorial Board and in this period he was Editor-in-Chief for 10 years (1990-1996 and 2001-2005). He is currently a member of the Editorial Advisory Board of the journal “Dermatitis”.
In 2000 De Groot was awarded the Leo Dermatology Award by the Dutch Society for Dermatology and Venereology for ‘his great contributions to the quality of dermatological care in the Netherlands’.

Patch Testing

In 1986, the first edition of “Patch Testing” was published. The text was largely produced with a Dbase program on an early Personal Computer (IBM XT) and the book was one of the first to be printed worldwide from camera-ready copy. The 2nd Edition followed in 1994 and was sold out in 2006. At that time, Elsevier upon request returned the copyright to Anton de Groot, who then published the third Edition of “Patch Testing” himself (acdegroot publishing). Ten years later, the fourth, expanded version with many improvements was released. The structure of “Patch Testing” has remained largely unchanged since the first 1986 Edition. The number of chemicals included in Table 1 (the “beating heart” of the book), however, has increased since then from 2200 to 4900, the number of references has quadrupled to nearly one thousand and the number of pages has doubled in these past 32 years to nearly 600.

Other books

De Groot has written a total of 31 books (22 titles, one with 5 editions, one with 3, and three books with 2 editions, and including his scientific autobiography), of which 7 are international books. Apart from “Unwanted Effects of Cosmetics and Drugs used in Dermatology” and “Patch Testing”, these are “Essential Oils: Contact Allergy and Chemical Composition” (2016, ISBN 9781482246407),  “Monographs in Contact Allergy, Volume 1. Non-fragrance Allergens in Cosmetics” (2018, ISBN 978-1-138-57325-3 and  9781138573383), ”Monographs in Contact Allergy, Volume 2. Fragrances and Essential Oils” (2019, ISBN 9780367149802), ”Monographs in Contact Allergy, Volume 3. Topical Drugs” (2021, ISBN 978-0-367-23693-9), and ”Monographs in Contact Allergy, Volume 4. Systemic Drugs” (2022, ISBN 978-0-367-43649-0), all published by CRC Press Taylor and Francis Group, Boca Raton, Fl.,U.S.A.

The other books that he wrote, mostly together with his friend and colleague Johan Toonstra MD, PhD, are general dermatology books in Dutch for medical students, general practitioners, “skin therapists” (huidtherapeuten, a paramedical profession largely restricted to The Netherlands) and pedicures and podotherapists; in addition, he wrote a booklet “Living with Eczema” for patients with atopic eczema and their parents.

The present

Anton de Groot has retired from dermatology practice, but since 2008 has regularly lectured general dermatology to junior medical doctors at the University of Groningen up to 2020, when the Covid-19 pandemic started. Since 2012, he has been consulting dermatologist and participant in CESES (Consumer Exposure Skin Effects and Surveillance), a Dutch Cosmetovigilance system monitoring side effects of cosmetics in The Netherlands, performed by the National Institute for Public Health and the Environment by order of the Netherlands Food and Consumer Product Safety Authority. This project was completed in December 2018. With a current 564 publications to his name (including 31 books, 70 book chapters and 138 articles in international journals) Anton will stop writing this spring and summer (2022) and decide in the fall whether he will engage in a new project, which, in that case, will be the 5th Volume in the Monographs series on Plastics, rubbers, et cetera. As a recent highlight in his career, in 2019 Anton received the American Contact Dermatitis Society  Honorary Membership status for his ”vast contributions to contact dermatitis”. Anton is married and he and his wife Janny have two daughters, both lawyers.